Effect of delaying prophylaxis against CMV in D+/R− solid organ transplant recipients in the development of CMV-specific cellular immunity and occurrence of late CMV disease

•We compared early and 14-days delayed long term prophylaxis in 95 D+/R− solid organ transplants.•We analyzed CMV-specific immunity and CMV disease among both groups of prophylaxis.•A 14-day delay in CMV prophylaxis is safe with no cases of early CMV disease.•There was a clear trend towards less end-organ CMV disease in patients receiving delayed prophylaxis.•CMV-specific immunity was not significantly improved by delaying CMV prophylaxis.

SummaryObjectivesEvaluate the protective effect against late CMV disease of delaying antiviral prophylaxis initiation in D+/R− patients receiving solid organ transplant (SOT).MethodsProspective multicenter study in D+/R− SOT recipients in Spain (Sept/09-Sept/12). Whole blood specimens were prospectively collected after Tx for CMV-specific cell-mediated immunity (CMI) determination. Two prophylaxis strategies were compared: early prophylaxis (EP; starting within the first 3 days after Tx) and delayed prophylaxis (DP; starting 14 days after Tx). Risk factors for the occurrence of CMV disease were determined by survival analysis and proportional risk Cox regression models.ResultsWe included 95 patients (50 EP V 45 DP). Twenty six patients (27.4%) developed CMV disease: 32.7% EP vs. 20% DP; (p = 0.2). No cases of CMV disease were reported previously to beginning delayed prophylaxis. The percentage of individuals with detectable CMI response was higher in patients with DP although differences did not reach statistic significance (42% vs 29.6% at day 200 after Tx; p = 0.4). There was a clear trend towards less end-organ CMV disease in patients receiving DP (18.2% EP vs 5% DP; p = 0.09) and DP was the only protective factor in the multivariate analysis (HR: 0.26; CI: 0.05-1.2; p = 0.09).ConclusionsA 14-day delay in CMV prophylaxis in D+/R− SOT recipients is safe and may reduce the incidence of late CMV end-organ disease although correlation of this effect with CMI responses was not complete.