Letter to the EditorPharmacokinetics and preliminary safety of high dose linezolid for the treatment of Gram-positive bacterial infections

•A pharmacokinetic study was performed in patients receiving linezolid 600 mg 8-hourly.•At the time of commencing the high dose, all patients had normal platelet count.•All patients but one, who discontinued linezolid, achieved clinical success.•Overexposure was more commonly seen in patients with toxicity compared to those without it.