Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6123962 | Journal of Infection and Chemotherapy | 2013 | 4 Pages |
Abstract
We report a case in which the atazanavir (ATV) concentration in the plasma decreased after unilateral nephrectomy in a patient receiving tenofovir (TDF). The patient was a 39-year-old man diagnosed with human immunodeficiency virus type 1 infection and was being treated with TDF/emtricitabine, ATV, and ritonavir. Before nephrectomy, ATV and TDF plasma trough concentrations were 810 and 65Â ng/ml, respectively. At this time, estimated glomerular filtration rate (eGFR) was 111Â ml/min/1.73Â m2. Approximately 5Â months after starting antiretroviral therapy (ART), the patient underwent nephrectomy. Plasma concentrations were remeasured 18Â weeks after the operation, and the TDF concentration had increased to 109Â ng/ml, whereas the ATV concentration decreased to 290Â ng/ml. His eGFR decreased to 50Â ml/min/1.73Â m2 at the time of the second measurement. The decreased ATV plasma concentration suggested that interactions between ATV and TDF were exacerbated by an increase in TDF plasma concentration caused by renal dysfunction. This case report suggests that it is important to monitor the ATV plasma concentration to ensure that it is no less than the target trough concentration when renal function decline is observed in patients receiving ART including ATV and TDF.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Applied Microbiology and Biotechnology
Authors
Yusuke Kunimoto, Hiroshi Yasui, Norifumi Touda, Masako Okazaki, Hiromasa Nakata, Norimasa Noda, Hiroshi Ikeda, Toshiaki Hayashi, Satoshi Takahashi, Yasuhisa Shinomura, Tadao Ishida, Atsushi Miyamoto,