Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6124403 | Osteoarthritis and Cartilage | 2016 | 32 Pages |
Abstract
This study provides the first direct in vivo evidence for macrophage involvement in OA in a substantial proportion of human knees. The association of quantity of activated macrophages with radiographic knee OA severity and joint symptoms suggests that drugs targeting macrophages and macrophage-associated inflammatory pathways may have the potential to be both symptom and structure modifying.
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Authors
V.B. Kraus, G. McDaniel, J.L. Huebner, T.V. Stabler, C.F. Pieper, S.W. Shipes, N.A. Petry, P.S. Low, J. Shen, T.A. McNearney, P. Mitchell,