| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6124476 | Osteoarthritis and Cartilage | 2016 | 27 Pages |
Abstract
Ageing negatively affects both the TGFβ-ALK5 and BMP-BMPR signalling routes, and aged chondrocytes display a lowered pSmad3-dependent response to TGFβ1. Because pSmad3 signalling is essential for cartilage homeostasis, we propose that this change contributes to OA development.
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Authors
A. van Caam, W. Madej, E. Thijssen, A. Garcia de Vinuesa, W. van den Berg, M.-J. Goumans, P. ten Dijke, E. Blaney Davidson, P.M. van der Kraan,