Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6124515 | Osteoarthritis and Cartilage | 2016 | 10 Pages |
Abstract
Gene expression changes in damaged cartilage suggested a signature non-chondrogenic response of altered matrix protein and secreted proteinase expression. There was evidence of a damage response in this late OA cartilage, which surprisingly showed features detected experimentally in the early response of cartilage to mechanical overload. PhenomeExpress analysis identified a hub of DEGs linked by a core of four differentially regulated TFs.
Related Topics
Health Sciences
Medicine and Dentistry
Immunology, Allergology and Rheumatology
Authors
S.L. Dunn, J. Soul, S. Anand, J.-M. Schwartz, R.P. Boot-Handford, T.E. Hardingham,