| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6124518 | Osteoarthritis and Cartilage | 2016 | 34 Pages |
Abstract
PKCε prevents the phenotypic progression of the OA chondrocyte, acting on cartilage specific markers through the modulation of the transcription factors SOX9 and RUNX2. The loss of PKCε enhances, in fact, the OA hypertrophic phenotype, with clear implications in the pathophysiology of the disease.
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Authors
V. Queirolo, D. Galli, E. Masselli, R.M. Borzì, S. Martini, F. Vitale, G. Gobbi, C. Carubbi, P. Mirandola,