Restriction of spontaneous and prednisolone-induced leptin production to dedifferentiated state in human hip OA chondrocytes: role of Smad1 and Î²-catenin activation

Article ID	Journal	Published Year	Pages	File Type
6124541	Osteoarthritis and Cartilage	2016	43 Pages	PDF

Abstract

Only dedifferentiated OA chondrocytes produced leptin. Prednisolone markedly enhanced leptin production, which involved Smad1 and Î²-catenin activation.

Keywords

Smad1 Hip osteoarthritis β-catenin Dedifferentiation Leptin Human chondrocytes

Related Topics

Health Sciences Medicine and Dentistry Immunology, Allergology and Rheumatology

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Restriction of spontaneous and prednisolone-induced leptin production to dedifferentiated state in human hip OA chondrocytes: role of Smad1 and Î²-catenin activation

Authors

E. Charlier, O. Malaise, M. Zeddou, S. Neuville, G. Cobraiville, C. Deroyer, C. Sanchez, P. Gillet, W. Kurth, D. de Seny, B. Relic, M.G. Malaise,