Norepinephrine modulates osteoarthritic chondrocyte metabolism and inflammatory responses

NE affects chondrocytes from OA cartilage regarding inflammatory response and its cell metabolism in a dose dependent manner. The sympathetic nervous system (SNS) may have a dual function in OA pathology with preserving a stable chondrocyte phenotype via β-AR signaling and OA pathogenesis accelerating effects via α-AR signaling.