Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6124549 | Osteoarthritis and Cartilage | 2016 | 10 Pages |
Abstract
Cartilage-subchondral bone plate alterations localized in the region of the point of mechanical load during ambulation in DMM-operated knees, at which the mechanical integrity of cartilage was impaired. These results indicate that DMM-induced increases in mechanical load play an important role in the pathogenesis of early post-traumatic osteoarthritis (OA), and it might accelerate the development of the disease via cartilage-subchondral bone plate crosstalk through increased subchondral plate perforations.
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Authors
H. Iijima, T. Aoyama, J. Tajino, A. Ito, M. Nagai, S. Yamaguchi, X. Zhang, W. Kiyan, H. Kuroki,