Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6124644 | Osteoarthritis and Cartilage | 2015 | 13 Pages |
Abstract
Cartilage contributes a minute percentage to the RNA extracted from the whole joint (<0.2%), yet is sensitive to changes in gene expression post-DMM. The post-DMM transcriptional reprogramming wanes over time dissipating by 8 weeks. Common pathways between published gene sets include focal adhesion, regulation of actin cytoskeleton and TGFβ. Common genes include Jagged 1 (Jag1), Tetraspanin 2 (Tspan2), neuroblastoma, suppression of tumourigenicity 1 (Nbl1) and N-myc downstream regulated gene 2 (Ndrg2). The concomitant genes and pathways we identify may warrant further investigation as biomarkers or modulators of OA.
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Authors
M.D. Gardiner, T.L. Vincent, C. Driscoll, A. Burleigh, G. Bou-Gharios, J. Saklatvala, H. Nagase, A. Chanalaris,