Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6124781 | Osteoarthritis and Cartilage | 2016 | 32 Pages |
Abstract
This study demonstrates for the first time that the ciliary protein IFT88 regulates fundamental actin organisation and the stiffness of the actin cortex leading to alterations in cell deformation, mechanical properties and blebbing in an IFT88 chondrocyte cell line. This adds to the growing understanding of the role of primary cilia and IFT in regulating cartilage biology.
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Authors
Z. Wang, A.K.T. Wann, C.L. Thompson, A. Hassen, W. Wang, M.M. Knight,