| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6124952 | Osteoarthritis and Cartilage | 2014 | 37 Pages |
Abstract
MSC chondrogenesis is inhibited by OA synovium CM through factors secreted by synovial macrophages and our findings suggest that M1 polarised subsets are potential mediators of this anti-chondrogenic effect. Modulation of macrophage phenotype may serve as a beneficial strategy to maximise the potential of MSCs for efficient cartilage repair.
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Authors
N. Fahy, M.L. de Vries-van Melle, J. Lehmann, W. Wei, N. Grotenhuis, E. Farrell, P.M. van der Kraan, J.M. Murphy, Y.M. Bastiaansen-Jenniskens, G.J.V.M. van Osch,