Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6125033 | Osteoarthritis and Cartilage | 2015 | 13 Pages |
Abstract
These data show that ASC-CM has a limited ability to decrease inflammatory and proteinases factors produced by OA chondrocytes or synoviocytes. ASC-CM is not sufficient to recapitulate the beneficial effect demonstrated using ASC in co-culture with inflamed OA chondrocytes and synoviocytes and shows that their use in clinical trials is fundamental to counteract OA progression.
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Authors
C. Manferdini, M. Maumus, E. Gabusi, F. Paolella, F. Grassi, C. Jorgensen, S. Fleury-Cappellesso, D. Noël, G. Lisignoli,