Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6125136 | Osteoarthritis and Cartilage | 2015 | 13 Pages |
Abstract
This study demonstrates for the first time that NP cells express a number of cytokine and chemokine receptors and thus could respond in an autocrine or paracrine manner to cytokines and chemokines produced by NP cells, particularly during tissue degeneration. However, this study failed to demonstrate regulatory effects on ECM genes and degradative enzymes or other cytokines and chemokines for any target investigated, with the exception of IL-1. This suggests that IL-1 is a master regulator within the IVD and may exert regulatory potential over a plethora of other cytokines and chemokines.
Keywords
CXCLTBSGAPDH18SCCRECMCCLDMEMADAMTSTNF-CXCRMMPIVDIL-C-X-C chemokine receptorcDNADulbecco's modified Eagle MediumCEP18S ribosomal RNAcomplementary deoxyribonucleic acidRNAribonucleic acidIntervertebral disc degenerationImmunohistochemistryIHCimmunoglobulin interferonIFNinterleukin-interleukin-1Tris-buffered salinestandard error of the meancluster of differentiationIntervertebral discCytokinecolony stimulating factortumour necrosis factornuclear factorVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)Annulus fibrosusExtracellular matrixmatrix metalloproteinaseCSFSEMNucleus pulposuspolymerase chain reactionPCRPost-mortemChemokine receptors
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Authors
K.L.E. Phillips, K. Cullen, N. Chiverton, A.L.R. Michael, A.A. Cole, L.M. Breakwell, G. Haddock, R.A.D. Bunning, A.K. Cross, C.L. Le Maitre,