Article ID Journal Published Year Pages File Type
6125188 Osteoarthritis and Cartilage 2013 8 Pages PDF
Abstract
Animal studies demonstrate that peripheral and central sensitization contributes to OA pain, involving inflammatory cytokines, neuropeptides, and a variety of chemical mediators. Interestingly, brainstem descending facilitation of 5-HT/5-HT3 receptors plays a role OA pain.
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Osteoarthritis pain mechanisms: basic studies in animal models
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