Article ID Journal Published Year Pages File Type
6125292 Osteoarthritis and Cartilage 2013 9 Pages PDF
Abstract
This study shows that doxycycline improves hMSC chondrogenesis and decreases MMP-13 in pellet cultures and within rat OCDs. Doxycycline exerted no negative effect on multiple measures of chondrogenesis and cartilage repair. These data support potential use of doxycycline to improve cartilage repair to delay the onset of osteoarthritis.
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Effects of doxycycline on mesenchymal stem cell chondrogenesis and cartilage repair
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