| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6125328 | Osteoarthritis and Cartilage | 2012 | 8 Pages |
Abstract
Injections of reIL-1β into equine carpal joints resulted in a transient inflammatory response that was similar in severity to the LPS injection, causing increased expression of certain deleterious mediators in joint tissues at 8 h. Given that IL-1β is a known critical mediator of traumatic arthritis and OA, this humane and temporary model may be useful in evaluating therapeutics that act against early stages of joint disease.
Related Topics
Health Sciences
Medicine and Dentistry
Immunology, Allergology and Rheumatology
Authors
T.N. Ross, J.D. Kisiday, T. Hess, C.W. McIlwraith,