Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6125467 | Osteoarthritis and Cartilage | 2013 | 9 Pages |
Abstract
A significantly greater likelihood of radiological progression of knee OA was associated with a commonly occurring IL1RN haplotype that could be tagged by three IL1RN SNPs (rs419598, rs9005, rs315943). Interactions were also observed between IL1RN gene variants and BMI relative to OA progression. This suggests that IL1RN gene markers may be useful in stratifying patients for medical management and drug development.
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Authors
X. Wu, V. Kondragunta, K.S. Kornman, H.Y. Wang, G.W. Duff, J.B. Renner, J.M. Jordan,