Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6125587 | Osteoarthritis and Cartilage | 2012 | 10 Pages |
Abstract
Osteophytic and articular chondrocytes significantly differ in their gene expression pattern. In articular cartilage, a prominent expression of antagonists inhibiting the BMP- and Wnt-pathway may serve to lock and stabilize the permanent chondrocyte phenotype and thus prevent their terminal differentiation. In contrast, osteophytic chondrocytes express genes with roles in the endochondral ossification process, which may account for their transient phenotype.
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Authors
K. Gelse, A.B. Ekici, F. Cipa, B. Swoboda, H.D. Carl, A. Olk, F.F. Hennig, P. Klinger,