Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6125624 | Osteoarthritis and Cartilage | 2010 | 8 Pages |
Abstract
Here we show that treatment with a MMP inhibitor reduces joint damage, osteochondral angiogenesis and behavioral evidence of pain. The association between osteochondral angiogenesis and pain behavior may be explained by perivascular nerve growth or stimulation of subchondral nerves following loss of osteochondral integrity. Our data suggest that targeting angiogenesis may have utility in the treatment of pain associated with structural damage in OA.
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Authors
P.I. Mapp, D.A. Walsh, J. Bowyer, R.A. Maciewicz,