Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6125642 | Osteoarthritis and Cartilage | 2010 | 10 Pages |
Abstract
The higher proportion of full-length monomers, longer GAG chains and greater stiffness of the BMSC-aggrecan makes it biomechanically superior to adult cartilage-aggrecan. Aggrecan stiffness was not solely dependent on fixed charge density, but also on GAG molecular ultrastructure. These results support the use of adult BMSCs for cell-based cartilage repair.
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Authors
H.-Y. Lee, P.W. Kopesky, A. Plaas, J. Sandy, J. Kisiday, D. Frisbie, A.J. Grodzinsky, C. Ortiz,