| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6125666 | Osteoarthritis and Cartilage | 2009 | 8 Pages |
Abstract
Intra-articular injection of IL-1β is a reproducible acute model of joint pathology that is potentially useful to evaluate IL-1 pathway inhibitors. The correlation of molecular events with clinical and pathological changes in this model has enhanced the understanding of the role of IL-1β in joint disease. Methods developed for gene expression analysis using multi-gene microfluidics cards and for biochemical analysis of joint lavage fluid might have utility for characterisation of other arthritis models and corresponding human disease.
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Authors
I. Scott, A. Midha, U. Rashid, S. Ball, A. Walding, P. Kerry, S. Delaney, S. Cruwys,