Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6125812 | Seminars in Immunology | 2016 | 7 Pages |
Abstract
Adoptive T cell therapy intends to therapeutically transfer defined T cell immunity into patients. Efficacy of this approach often requires long-term maintenance of transferred cells, which depends on the presence and persistence of memory T cells. However, engraftment and survival of highly differentiated memory T cell subsets upon adoptive transfer is still difficult to achieve. Therefore, the recent observation that a distinct subset of weakly differentiated memory T cells shows all characteristics of adult tissue stem cells and can reconstitute all types of effector and memory T cell subsets, became highly relevant. We here review our current understanding of memory subset formation and T cell subset purification, and its implications for adoptive immunotherapy.
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Authors
Dirk H. Busch, Simon P. FräÃle, Daniel Sommermeyer, Veit R. Buchholz, Stanley R. Riddell,