Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6125917 | Seminars in Immunology | 2011 | 12 Pages |
Abstract
- Tolerogenic dendritic cells (DC) promote both central and peripheral tolerance.
- In rodents, donor or recipient-derived tolerogenic DC can promote long-term organ allograft survival.
- Peripheral blood DC with tolerogenic features have been detected in liver transplant patients with operational tolerance.
- Tolerogenic DC have been shown to promote antigen-specific T cell tolerance to model antigens in human volunteers.
- Pre-clinical trials in non-human primates will guide testing of tolerogenic DC therapy in human organ transplantation.
Keywords
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Authors
Mohamed Ezzelarab, Angus W. Thomson,