Making sense of regulatory T cell suppressive function

Article ID	Journal	Published Year	Pages	File Type
6125921	Seminars in Immunology	2011	11 Pages	PDF

Abstract

âº Regulatory T cells appear responsible for peripheral tolerance. âº Mechanisms of CD4+CD25+Foxp3+ cells include inhibitory cytokines and induced death of effectors. âº Regulatory mechanisms also result from altered extracellular nucleotide/nucleoside fluxes and intracellular cyclic AMP. âº Regulatory T cells function in concert with dendritic cells. âº These cells have great potential as therapeutic approaches in transplantation and immune-mediated diseases.

Keywords

BMT GITR MBP NKT FGL2 mTOR TCr CD39 Treg IEL IDO SCID IBD FCR TLR PAMP APC EAE GvHD CTLA-4 HSC TGF-β TNF CTL Th3 LPS LAG-3 FOXP3 FITC Tr1 cyclic AMP cAMP CD4+CD25+Foxp3+ regulatory T cells H&E cytotoxic T-lymphocyte antigen 4 Human leukocyte antigen Antigen presenting cells HLA experimental autoimmune encephalomyelitis Graft-versus-host-disease Immunohistochemistry IHC interferon IFN interleukin indoleamine 2,3-dioxygenase Inflammatory bowel disease Tolerance Toll-like receptor forkhead box P3 natural killer T cells hematopoietic stem cells Dendritic cells Endothelial cells Regulatory T cells tumor growth factor tumor necrosis factor fluorescein isothiocyanate fibrinogen-like protein 2 Cytotoxic T lymphocytes lipopolysaccharide major histocompatibility complex MHC bone marrow Multiple sclerosis NAD SCID, Severe combined immunodeficiency NAD, nicotinamide adenine dinucleotide mammalian target of rapamycin Hematoxylin and Eosin pathogen associated molecular patterns Myelin basic protein Transplantation bone-marrow transplantation Lymphocyte activation gene-3 Fc receptor T cell receptor Glucocorticoid-induced tumor necrosis factor receptor