| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6125922 | Seminars in Immunology | 2011 | 11 Pages |
Abstract
⺠Costimulatory pathways have a critical role in the regulation of alloreactivity. ⺠A complex network of positive and negative pathways regulates T cell responses. ⺠Blocking costimulation improves allograft survival in rodents and non-human primates. ⺠The costimulation blocker belatacept is being developed as immunosuppressive drug in renal transplantation.
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Authors
Nina Pilat, Mohamed H. Sayegh, Thomas Wekerle,