Moving to tolerance: Clinical application of T regulatory cells

Article ID	Journal	Published Year	Pages	File Type
6125923	Seminars in Immunology	2011	10 Pages	PDF

Abstract

âº Historical perspective on regulatory T cell potential to combat allograft rejection. âº In vivo induction of regulatory T cells in allograft recipients. âº In vitro expansion/generation of regulatory T cells for cellular therapy. âº The current experience of regulatory T cell therapies in the clinic. âº Safety concerns and monitoring results of regulatory T cell therapy.

Keywords

AZT Tconv nTreg immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome IPEX CyA TSDR PI3K DST Treg CNI phosphatidyl inositol 3′ kinase donor specific transfusion mTOR TCr GvHD APC ATG MMF 3′-azido-3′-deoxythymidine Cellular therapy T regulatory cell T regulatory cells antigen presenting cell cyclosporin A mycophenolate mofetil calcineurin inhibitor mammalian target of rapamycin Translational medicine Transplantation Graft versus host disease T cell receptor