| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6125950 | Transplant Immunology | 2016 | 4 Pages |
Abstract
This case report describes DQ6-reactive serum antibody reactivity in a patient who types as DQ6. DNA typing showed DQB1*06:09 on the antibody producer and serum reactivity with DQB1*06:01, *06:02 and *06:03 but not with *06:04 and *06:09. HLAMatchmaker serum analysis showed antibody reactivity with a new antibody-verified 85VA eplet on DQB but additional reactivity with DQB1*02:01 could not be readily interpreted. After applying the nonself-self algorithm of HLA immunogenicity we have identified a new DQB epitope structurally described as 140A2Â +Â 130RÂ +Â 135D and shared by DQB1*02:01 and DQB1*05:01 and DQB1*06:02 of the immunizer.
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Authors
Liesbeth Daniëls, Marie-Paule Emonds, Jean-Louis Bosmans, Marilyn Marrari, Rene J. Duquesnoy,