| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6125951 | Transplant Immunology | 2016 | 36 Pages |
Abstract
We established an allograft rejection model with impaired renal function and typical histopathological changes of chronic rejection in fully MHC-mismatched rats by controlling administration of an immunosuppressant. These findings suggest that this model more accurately reflects transplantation in a clinical setting than existing models and enables the evaluation of therapeutic agents.
Keywords
peritubular capillariesAMRMCP-1KIM-1PTCIF/TAOPNTIMP-1DSADonor-specific antibodydonor specific antibodiesOsteopontinMRItissue inhibitor of metalloproteinase-1chronic kidney diseaseMagnetic resonance imagingantibody-mediated rejectionAcute rejectionchronic rejectioninterstitial fibrosis/tubular atrophymajor histocompatibility complexMHCKidney injury molecule 1CKDKidney transplantation
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Authors
Kaori Hanaoka, Yuka Kawato, Kaori Kubo, Tomonori Nakanishi, Masashi Maeda, Koji Nakamura, Jun Hirose, Takahisa Noto, Hidehiko Fukahori, Akihiko Fujikawa, Sosuke Miyoshi, Shoji Takakura, Tatsuaki Morokata, Yasuyuki Higashi,