Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6125962 | Transplant Immunology | 2016 | 7 Pages |
Abstract
Toll-like receptor 1 (TLR1) genetic variant (rs5743551, â 7202A > G) has been reported to be associated with susceptibility to various infectious diseases. We retrospectively examined the impact of TLR1 variation on transplant outcomes in a cohort of 320 patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies. A multivariate analysis showed that the G/G genotype in the recipients and the donors was associated with a significantly lower 3-year transplant-related mortality (TRM). The recipient G/G genotype also resulted in a better 3-year progression-free survival. This study suggests that the recipient and donor TLR1 G/G genotypes are comparably associated with a reduced risk of death that was not related to relapse. Thus, TLR1 genotyping may be useful for selecting the donor, managing patients in a risk-adapted manner, and creating therapeutic strategies to prevent complications after hematopoietic stem cell transplantation.
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Authors
Kaori Uchino, Shohei Mizuno, Motonori Mizutani, Tomohiro Horio, Ichiro Hanamura, J. Luis Espinoza, Keitaro Matsuo, Makoto Onizuka, Koichi Kashiwase, Yasuo Morishima, Takahiro Fukuda, Yoshihisa Kodera, Noriko Doki, Koichi Miyamura,