Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6125982 | Transplant Immunology | 2015 | 15 Pages |
Abstract
This report describes a case of a highly sensitized patient who had serum antibodies reacting with HLA-A2 but whose phenotype included HLA-A2. The determination of HLA mismatch acceptability at the antigen level was problematic, but high-resolution HLA typing information and epitope-based antibody specificity analysis based on the nonself-self paradigm of HLA epitope immunogenicity have provided a solution. This case supports the concept that HLA typing at the allele level offers a better approach to identifying suitable donors for sensitized patients.
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Authors
A.B. Hahn, V. Bravo-Egana, J.L. Jackstadt, D.J. Conti, R.J. Duquesnoy,