Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6125995 | Transplant Immunology | 2014 | 5 Pages |
Abstract
Past studies showed, that during acute organ rejection intracellular interleukin-2 is increased in cytotoxic T-cells, supposed to be a marker for this event. We were able to show, that intracellular interleukin-2 in CD8+ T-cells is also increased after organ rejection. Furthermore it seems to depend on the quantity of rejection events. Further studies in recipients with increased intracellular interleukin-2 in cytotoxic CD8+ T-cells and documented history of organ rejection are needed to identify this as a possible risk factor for further rejection events.
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Authors
Bora Akoglu, Barbara Lafferton, Shara Kalb, Said Emal Yosuf, Eva Herrmann, Stefan Zeuzem, Jan GoÃmann, Heinz-Georg Kachel, Ernst-H. Scheuermann, Dominik Faust,