| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6126083 | Transplant Immunology | 2012 | 8 Pages |
Abstract
⺠The contribution of Vav1 GEF activity to allograft rejection was addressed. ⺠T cells with disrupted GEF activity showed reduced proliferation and activation. ⺠Mice with disrupted Vav1 GEF activity showed prolonged cardiac allograft survival. ⺠Vav1 GEF activity significantly contributes to T cell-mediated allograft rejection.
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Authors
Dirk Haubert, Jianping Li, Alexander Saveliev, Thomas Calzascia, Esther Sutter, Barbara Metzler, Daniel Kaiser, Victor L.J. Tybulewicz, Gisbert Weckbecker,