| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6127488 | Acta Tropica | 2014 | 5 Pages |
Abstract
- Leishmania promastigotes were susceptible to seven H1-antagonists.
- Cinnarizine was effective against the amastigotes, with an IC50 value of 21 μM.
- H1-antagonists showed moderate mammalian cytotoxicity (IC50 values 57 to 229 μM).
- Free cinnarizine failed to treat Leishmania-infected hamsters at 100Â mg/kg.
- The liposomal cinnarizine (3Â mg/kg) reduced the parasite burden to 54% in liver.
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Authors
Erika G. Pinto, Thais A. da Costa-Silva, Andre Gustavo Tempone,