| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6127742 | Acta Tropica | 2013 | 9 Pages |
Abstract
⺠We characterized the FtsZ gene of Wolbachia of W. bancrofti. ⺠We assessed its polymorphism in parasites from different endemic regions of India. ⺠The gene shared functional motifs with β-tubulin of eukaryotes. ⺠Hence, albendazole may affect dual targets, Wolbachia FtsZ and parasite β-tubulin. ⺠Tests with mosquito Wolbachia confirmed the sensitivity of FtsZ to albendazole. ⺠In view of these FtsZ is a good target for antifilarial drug development.
Related Topics
Life Sciences
Immunology and Microbiology
Parasitology
Authors
Rohit Sharma, S.L. Hoti, V. Vasuki, T. Sankari, R.L. Meena, P.K. Das,