| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6128231 | Acta Tropica | 2011 | 6 Pages |
Abstract
⺠A human-mouse chimeric Fab of monoclonal anti-idiotypic antibody NP30 (chFab-NP30) against Schistosoma japonicum was constructed and expressed in E. coli. ⺠The purified chFab-NP30 inhibited the binding of parent NP30 to sera from schistosomiasis patients in a dose-dependent manner. ⺠Administration of the chimeric Fab in vivo increased the survival rate, reduced egg burdens and ameliorated organ pathology of mice with acute schistosomiasis. ⺠chFab-NP30 is a promising candidate to be used as a specific and efficient recombinant antibody against acute schistosomiasis japonica.
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Authors
Xu Jing, Zhu Xiao-Juan, Li Yu-Hua, Dai Yang, Zhu Yin-Chang, Zheng Jiang, Feng Zhen-Qing, Guan Xiao-Hong,