Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6128254 | Acta Tropica | 2011 | 7 Pages |
Abstract
⺠The cysteine-rich interdomain region 1α (CIDR1α) of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) interacts with enriched human B cells. ⺠CIDR1α promotes TLR7 and TLR10 mRNA transcripts and sensitizes B cells to TLR9 signalling via MyD88. ⺠CIDR1α is able to induce the phosphorylation of ERK1/2, p38 and IKBα. ⺠A persistent and aberrant activation of B cells during chronic malaria may contribute to the impairment B cell functions.
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Authors
Olivia Simone, Maria Teresa Bejarano, Susan K. Pierce, Salvatore Antonaci, Mats Wahlgren, Marita Troye-Blomberg, Daria Donati,