| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6134384 | Journal of Virological Methods | 2013 | 6 Pages |
Abstract
⺠Our engineered vaccine candidate, VAL-44, consists of multiple epitopes from HCV NS5A, NS4B and core proteins. ⺠VAL-44 induced antigen-specific IFN-γ-producing CD4+ T cells and CD8+ T cells. ⺠VAL-44 elicited a Th1-biased immune response with secretion of high amounts of IFN-γ and IL-2. ⺠Our findings suggest that VAL-44 may be developed as a potential HCV multi-epitope peptide vaccine.
Keywords
IFN-αSFCsHLA-A2IFAT helperELISPOTPBMCsIFN-γALTCTLCFAcomplete Freund's adjuvantincomplete Freund's adjuvantDMSOAlanine aminotransferaseEnzyme-linked immunospotInterferon-αinterferon-γDimethyl sulfoxideperipheral blood mononuclear cellsstimulation indexlactate dehydrogenaseLDHHepatitis C virusHCVPeptide vaccineoptical density
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Authors
Xiao-jun Huang, Xin Lü, Ying-feng Lei, Jing Yang, Min Yao, Hai-yun Lan, Jian-min Zhang, Zhan-sheng Jia, Wen Yin, Zhi-kai Xu,