Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6135753 | Microbes and Infection | 2014 | 5 Pages |
Abstract
Mammalian cells store excess fatty acids in the form of triglycerides within lipid droplets. The intracellular bacterium Orientia tsutsugamush is the causative agent of severe human rickettiosis. We found that O. tsutsugamushi infection induces the formation of lipid droplets in mouse L-929 fibroblasts. In infected cells, a parallel increase in the number of lipid droplets and pathogens was observed. Interestingly, the pathogen-infection induced the accumulation of triglycerides even without external supply of fatty acids. These results suggest that O. tsutsugamushi alters lipid metabolism of host cells to induce lipid droplets.
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Authors
Motohiko Ogawa, Masayoshi Fukasawa, Masaaki Satoh, Kentaro Hanada, Masayuki Saijo, Tsuneo Uchiyama, Shuji Ando,