Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6135762 | Microbes and Infection | 2012 | 15 Pages |
Abstract
Protein phosphorylation plays a fundamental role in the biology of apicomplexan parasites. Many apicomplexan protein kinases are substantially different from their mammalian orthologues, and thus constitute a landscape of potential drug targets. Here, we integrate genomic, biochemical, genetic and evolutionary information to provide an integrated and up-to-date analysis of twelve apicomplexan kinomes. All kinome sequences are available through the Kinomer database.
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Authors
Diego Miranda-Saavedra, Toni Gabaldón, Geoffrey J. Barton, Gordon Langsley, Christian Doerig,