| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6135778 | Microbes and Infection | 2012 | 8 Pages |
Abstract
The vacuolating cytotoxin VacA, a polypeptide of about 88Â kDa, is one of the major virulence factors of Helicobacter pylori. VacA essentially acts as an invasive chloride channel targeting mitochondria. The results of recent studies open a new perspective on the mechanisms by which VacA causes loss of the mitochondrial membrane potential, mitochondrial fragmentation, formation of reactive oxygen species, autophagy, cell death and gastric cancer.
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Authors
Joachim Rassow, Michael Meinecke,