| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6135786 | Microbes and Infection | 2012 | 7 Pages |
Abstract
It has been reported that treatment with tricin (4â²,5,7-trihydroxy-3â²,5â²-dimethoxyflavone), a derivative of Sasa albo-marginata, after human cytomegalovirus (HCMV) infection significantly suppressed both infectious virus production and HCMV replication in the human embryonic fibroblast cell line MRC-5. In this paper, we examined the mechanisms for the anti-HCMV effects of tricin in MRC-5 cells. Exposure of fibroblasts to tricin inhibited infectious HCMV production, with concomitant decreases in levels of transcripts of the CXC chemokine IFN-inducible T cell alpha chemoattractant (I-TAC or CXCL11) gene. We also found that the transcripts of the HCMV immediate early (IE) gene and replication of HCMV were lower in CXCL11 gene-knockdown cells. These results suggest that tricin is a novel compound with potential anti-HCMV activity and that CXCL11 is one of the chemokines involved in HCMV replication. In addition, it is possible that CXCL11 is the one of the targets of tricin.
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Authors
Tsugiya Murayama, Ying Li, Takashi Takahashi, Rie Yamada, Keiko Matsubara, Yuuzo Tuchida, Zhuan Li, Hidetaka Sadanari,