| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6135927 | Microbes and Infection | 2011 | 4 Pages |
Abstract
Trypanosoma cruzi the cause of Chagas disease persists in tissues of infected experimental animals and humans. Here we demonstrate the persistence of the parasite in adipose tissue from of three of 10 elderly seropositive patients with chronic chagasic heart disease. Nine control patients had no parasites in the fat. We also demonstrate that T. cruzi parasitizes primary adipocytes in vitro. Thus, in humans as in mice the parasite may persist in adipose tissue for decades and become a reservoir of infection.
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Authors
Adaliene Versiani Matos Ferreira, Marcela Segatto, Zélia Menezes, Andréa Mara Macedo, Cláudio Gelape, Luciana de Oliveira Andrade, Fnu Nagajyothi, Philipp E. Scherer, Mauro Martins Teixeira, Herbert B. Tanowitz,