| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6135968 | Microbes and Infection | 2012 | 6 Pages |
Abstract
The course of leprosy depends of the host immune response which ranges from the lepromatous pole (LL) to the tuberculoid pole (TT). A comparative study was conducted in 60 patients with the LL and TT. The results showed a mean expression of TGF-β of 339 ± 99.4 cells/field for TT and of 519.2 ± 68.2 cells/field for LL. Frequency of apoptosis was 6.3 ± 1.8 in TT and 14.0 ± 6.1 in LL. A correlation (p = 0.0251) between TGF-β and caspase-3 in the LL was found. This finding indicates a role of TGF-β and apoptosis in the immune response in leprosy.
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Authors
Juarez Antonio Simoes Quaresma, FabrÃcio Anderson Carvalho de Almeida, Tinara Leila de Souza Aarao, Luis Paulo de Miranda Araujo Soares, Ismaelino Mauro Nunes Magno, Hellen Thais Fuzii, Rosana Maria Feio Libonati, Marilia Brasil Xavier, Carla Pagliari,