Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6136040 | Microbes and Infection | 2010 | 9 Pages |
Abstract
The non-polymorphic MHC molecule Qa-1 and its human counterpart HLA-E present monomorphic signal peptides to innate receptors and thereby regulate lymphocyte activity. Under stress, this peptide content is replaced with a surprisingly diverse repertoire of novel peptides that are associated with heat-shock proteins, infectious agents or antigen processing defects.
Keywords
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Immunology
Authors
Thorbald van Hall, Claudia C. Oliveira, Simone A. Joosten, Tom H.M. Ottenhoff,