Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6136105 | Microbes and Infection | 2008 | 6 Pages |
Abstract
We tested the hypothesis that host resistance to Campylobacter jejuni is Nramp1 dependent. Following intraperitoneal (IP) inoculation of Nramp1+/+ and isogenic Nramp1-deficient (Nramp1â/â) mice C. jejuni primarily associated with mac1-positive cells in liver tissue. A significant reduction of C. jejuni was observed in Nramp1+/+ mice 4 days post-infection (PI) (liver) and 8 days PI cecum-colon. In contrast, Nramp1â/â mice showed no significant reduction of C. jejuni and instead had a chronic inflammatory response and significant histopathological lesions 30 days PI. Differential cytokine profiles were observed in C. jejuni infected Nramp1+/+ and Nramp1â/â primary dendritic cells. Taken together these data indicate that Nramp1 is critical for host resistance to C. jejuni.
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Authors
Olivia L. Champion, Yanet Valdez, Lisa Thorson, Julian A. Guttman, Alfredo Menendez, Erin C. Gaynor, B. Brett Finlay,