Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6138547 | Virology | 2016 | 11 Pages |
Abstract
GADD45 proteins are a group of stress-induced proteins and participate in various cellular pathways including cell cycle regulation, cell survival and death, DNA repair and demethylation. It was recently shown that HIV-1 infection induces the expression of GADD45 proteins. However, the effect of GADD45 on HIV-1 replication has not been studied. Here, we report that overexpression of GADD45 proteins reduces HIV-1 production through suppressing transcription from the HIV-1 LTR promoter. This inhibitory effect is specific to HIV-1, since GADD45 proteins neither inhibit the LTR promoters from other retroviruses nor reduce the production of these viruses. Knockdown of endogenous GADD45 modestly activates HIV-1 in the J-Lat A72 latency cell line, which suggests GADD45 proteins might play a role in maintaining HIV-1 latency.
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Virology
Authors
Zhibin Liang, Ruikang Liu, Hui Zhang, Suzhen Zhang, Xiaomei Hu, Juan Tan, Chen Liang, Wentao Qiao,