Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6138905 | Virology | 2016 | 10 Pages |
Abstract
With this aim we collected a small library of commercially available compounds starting from a large database and performing a diversity-based selection to reduce the number of screened compounds avoiding structural redundancy of the library. Selected compounds were tested for their hemagglutination-inhibiting (HI) ability against two different A/H1N1 viral strains (one of which is oseltamivir sensitive), and 17 of them showed the ability to interact with HA. Five drug-like molecules, in particular, were able to impair hemagglutination of both A/H1N1 viral strains under study and to inhibit cytopathic effect and hemolysis at sub-micromolar level.
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Authors
Mariangela Agamennone, Agostina Pietrantoni, Fabiana Superti,