| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6139209 | Virology | 2015 | 15 Pages |
Abstract
Here, we outline PR structures and substrate specificities focusing on HIV PR as a therapeutic target. We discuss design and clinical success of HIV PR inhibitors, as well as resistance development towards these drugs. Finally, we summarize data elucidating the role of proteolysis in maturation and highlight unsolved questions regarding retroviral maturation.
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Virology
Authors
Jan Konvalinka, Hans-Georg Kräusslich, Barbara Müller,